We're living this right now! Just moved into our house and ripped out the master bath and closet to combine into a larger bathroom, complete demo/reno of hallway main bath, broke into 4th BR from master to create a large walk in closet, took out the doorway to the 4th bedroom to open the space as a hallway continuation, total teardown of kitchen/dining room to renovate and enlarge access to LR, rip up all carpet and plywood to install hardwood floors. So far the bathrooms have been completed... except for the glass shower partition that we're waiting for, and the floors are done. Closet itself is finished, but the bifold barn doors still need to be installed. Hardwood floors have been installed. Kitchen is probably about 75% done. Once those projects are all complete, we'll continue on the ground floor. We already had the poorly constructed wood burning fireplace and surround ripped out and replaced with a gas insert. Tile in the foyer, laundry room, and powder room will all be taken up and replaced. Powder room will be demoed and then enlarged, and the fireplace will get a new surround. Tons of cosmetic work being done everywhere - wallpaper removal, crown molding removal, spackle, spackle, spackle!
You're going to live with dust. We've had plastic film walls set up all over. Damn dust gets around it!